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If Valium is to be combined with other centrally-acting agents, for example, antipsychotics, anxiolytics/sedatives, antidepressants, hypnotics, anticonvulsants, narcotic analgesics, anesthetics and sedative antihistamines, it should be borne in mind that their effects may potentiate or be potentiated by the action of Valium.
The use of Valium with alcohol is not recommended due to enhancement of the sedative effect.
There is a potentially relevant interaction between diazepam and compounds which inhibit certain hepatic enzymes, particular cytochrome P-450 IIIA. Data indicates that these compound influence the pharmacokinetics of diazepam and may lead to increased and prolonged sedation. The increased and prolonged sedation is identified to occur with cimetidine, ketoconazole, fluvoxamine, fluoxetine and omeprazole.
Reports that the metabolic elimination of phenytoin is affected by diazepam have been reported. On the other hand, there is no known interference with commonly used antidiabetics, anticoagulant or diuretic substances. Disapride may lead to a temporary increase in the sedative effects or orally administered benzodiazepines due to faster absorption.
Histories of hypersensitivity to benzodiazepines, severe respiratory and hepatic insufficiency, sleep apnea syndrome, myasthenia gravis are some of Diazepam’s contraindications. Dependence on other substances including alcohol is another. An exception to the latter is the management of acute withdrawal reactions.
Benzodiazepines must not be used alone to treat depression or anxiety associated with depression because suicide may take place in such patients. These are not advised for the primary treatment of psychotic illness.
Benzodiazepines should be used with intense warning in patients with a history of alcohol or drug abuse. Lower dose of Valium is recommended for patients with chronic respiratory insufficiency, due to the risk of respiratory depression.
In patients with myasthenia gravis who are prescribed with Valium, care should be taken on account of preexisting muscle weakness.
Although available over-the-counter, consultation with your doctor is a must.
